Engineering human stem cells to model the kidney’s filtration barrier on a chip

A team at Harvard’s Wyss Institute of Biologically Inspired Engineering now reports an approach in Nature Biomedical Engineering, which enables the differentiation of human induced pluripotent stem (iPS) cells into mature podocytes with more than 90 percent efficiency. Linking the differentiation process with organ-on-a-chip technology pioneered by his team, the researchers went on to engineer the first in vitro model of the human glomerulus, demonstrating effective and selective filtration of blood proteins and podocyte toxicity induced by a chemotherapy drug in vitro.
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With health insurance at risk, community health centers face cut-backs

Repeal of key provisions of the Affordable Care Act, combined with a failure to renew critical funding streams, would result in catastrophic funding losses for community health centers-forcing these safety net providers to cut back on services, lay off staff or shut down clinical sites, according to a report published today. The report represents the first analysis of the potential effects on medically underserved communities of the types of health insurance losses contained in legislation now pending in Congress.
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