Mammalian protein found in Homo sapiens
CNR1 Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LVQ , 1LVR , 2B0Y , 2KOE , 2MZ3 , 2MZ2 , 2MZA ,%%s1LVQ , 1LVR , 2B0Y , 2KOE
Identifiers Aliases CNR1 , CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, cannabinoid receptor 1 (brain), cannabinoid receptor 1, cannabinoid CB1 receptor geneExternal IDs OMIM : 114610 ; MGI : 104615 ; HomoloGene : 7273 ; GeneCards : CNR1 ; OMA :CNR1 - orthologs Wikidata
Cannabinoid receptor 1 (CB1 ), is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene .[5] The human CB1 receptor is expressed in the peripheral nervous system and central nervous system .[5] It is activated by endogenous cannabinoids[6] called endocannabinoids , a group of retrograde neurotransmitters that include lipids, such as anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids , such as docosatetraenoylethanolamide found in wild daga , the compound THC which is an active constituent of the psychoactive drug cannabis ; and synthetic analogs of THC . CB1 is antagonized by the phytocannabinoid tetrahydrocannabivarin (THCV).[7] [8]
The primary endogenous agonist of the human CB1 receptor is anandamide .[5]
^ a b c GRCh38: Ensembl release 89: ENSG00000118432 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044288 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ a b c Abood M, Barth F, Bonner TI, Cabral G, Casellas P, Cravatt BF, et al. (22 August 2018). "CB1 Receptor" . IUPHAR/BPS Guide to Pharmacology . International Union of Basic and Clinical Pharmacology. Retrieved 9 November 2018 .
^ Busquets Garcia A, Soria-Gomez E, Bellocchio L, Marsicano G (24 May 2016). "Cannabinoid receptor type-1: breaking the dogmas" . F1000Research . 5 : 990. doi :10.12688/f1000research.8245.1 . PMC 4879932 . PMID 27239293 .
^ Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, et al. (December 2005). "Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist" . British Journal of Pharmacology . 146 (7): 917–926. doi :10.1038/sj.bjp.0706414 . PMC 1751228 . PMID 16205722 .
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