| Caltractin | |||||||
|---|---|---|---|---|---|---|---|
 Crystal structure of the SdCen/skMLCK complex.[1] | |||||||
| Identifiers | |||||||
| Organism | |||||||
| Symbol | caltractin | ||||||
| RefSeq (mRNA) | X69220 | ||||||
| UniProt | Q06827 | ||||||
| |||||||
Centrins, also known as caltractins, are a family of calcium-binding phosphoproteins found in the centrosome of eukaryotes.[2][3] Centrins are small calcium binding proteins that are ubiquitous centrosome components. There are about 350 “signature” proteins that are unique to eukaryotic cells but have no significant homology to proteins in archaea and bacteria.[4] They are a type of protein that is essential and present in almost all eukaryotic cells and are found in the centrioles and pericentriolar lattice.[5] Human centrin genes are CETN1, CETN2 and CETN3.[2][3]
Humans and mice have three centrin genes: Cetn-1, which is typically only expressed in male germ cells, and Cetn-2 and Cetn-3, which are typically only expressed in somatic cells. Centrin-2 is a recombinant GFP-centrin-2 and centriole protein that localizes to centrioles throughout the cell cycle, while centrin-3 seems to stick to the pericentriolar material that surrounds the centrioles.[5]
- ^ "RCSB Protein Data Bank - Structure Summary for 3KF9 - Crystal structure of the SdCen/skMLCK complex".
- ^ a b Baron, A. T.; Greenwood, T. M.; Bazinet, C. W.; Salisbury, J. L. (1992). "Centrin is a component of the pericentriolar lattice". Biology of the Cell. 76 (3): 383–388. doi:10.1016/0248-4900(92)90442-4. PMID 1305481. S2CID 85374106.
- ^ a b Salisbury JL, Suino KM, Busby R, Springett M (2002). "Centrin-2 is required for centriole duplication in mammalian cells". Curr. Biol. 12 (15): 1287–92. doi:10.1016/S0960-9822(02)01019-9. PMID 12176356. S2CID 1415623.
- ^ Salisbury, Jeffery L (2002). "Centrin-2 Is required for Centriole Duplication in Mammalian Cells". Current Biology. 12 (15): 1287–1292. doi:10.1016/s0960-9822(02)01019-9. PMID 12176356. S2CID 1415623.
- ^ a b "Centrin Protein | CETN1 Peptide | CETN2 Antigen | ProSpec". www.prospecbio.com. Retrieved 2023-05-02.