Back هيموفيليا أ Arabic Hemofiliya A Azerbaijani Hemofília A Catalan Hemofilia A Spanish هموفیلی ای Persian Հեմոֆիլիա A Armenian Emofilia A Italian 血友病A Japanese Hemofilia A Malay Hemofilia A Portuguese
| Haemophilia A | |
|---|---|
| Other names | Hemophilia A |
 | |
| Protein structure of coagulation factor VIII, of which its deficiency is the cause of haemophilia A. | |
| Specialty | Haematology |
| Symptoms | Prolonged bleeding from common injuries[1] |
| Causes | Factor VIII deficiency[2] |
| Diagnostic method | Bleeding time,[2] coagulation screen, genetic testing |
| Prevention | Hepatitis B vaccine should be considered[2] |
| Treatment | Factor VIII, factor VIII inhibitors, emicizumab |
Haemophilia A (or hemophilia A) is a blood clotting disorder caused by a genetic deficiency in clotting factor VIII, thereby resulting in significant susceptibility to bleeding, both internally and externally. This condition occurs almost exclusively in males born to carrier mothers due to X-linked recessive inheritance. Nevertheless, rare isolated cases do emerge from de novo (spontaneous) mutations.[2][3][4]
The medical management of individuals with hemophilia A frequently entails the administration of factor VIII medication through slow intravenous injection. This intervention aims to address and preempt additional bleeding episodes in affected individuals.
- ^ Cite error: The named reference
genwas invoked but never defined (see the help page). - ^ a b c d "Hemophilia A: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 24 June 2016.
- ^ "Haemophilia A (Factor VIII Deficiency) information | Patient". Patient. Retrieved 24 June 2016.
- ^ World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 259–60. hdl:10665/44053. ISBN 9789241547659.