Back هيدروكودون Arabic هیدروکودون AZB Hydrokodon Czech Hydrocodon Welsh Hydrocodon German Υδροκωδόνη Greek Hidrocodona Spanish Hidrokodona Basque هیدروکدون Persian Hydrokodoni Finnish

Hydrocodone

Not to be confused with Dihydrocodeine.

Hydrocodone
Clinical data
Trade namesHysingla ER, Zohydro ER
Other namesDihydrocodeinone, hydrocodone bitartrate
AHFS/Drugs.comMonograph
MedlinePlusa601006
License data
Dependence
liability		High[1]
Addiction
liability		High
Routes of
administration		Clinical: by mouth[2]
Others: intranasal, rectal
Drug classOpioid
ATC code
Legal status
Legal status
Pharmacokinetic data
BioavailabilityBy mouth: 70%[4]
Protein bindingLow[4][5]
MetabolismLiver: CYP3A4 (major), CYP2D6 (minor)[6]
Metabolites• Norhydrocodone[6]
• Hydromorphone[6]
• Others[6]
Onset of action10–20 minutes[2]
Elimination half-lifeAverage: 3.8 hours[7]
Range: 3.3–4.4 hours[2]
Duration of action4–8 hours[2]
ExcretionUrine[8][9]
Identifiers
  • 4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.304 Edit this at Wikidata
Chemical and physical data
FormulaC18H21NO3
Molar mass299.370 g·mol−1
3D model (JSmol)
  • O=C4[C@@H]5Oc1c2c(ccc1OC)C[C@H]3N(CC[C@]25[C@H]3CC4)C
  • InChI=1S/C18H21NO3/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19/h3,6,11-12,17H,4-5,7-9H2,1-2H3/t11-,12+,17-,18-/m0/s1 checkY
  • Key:LLPOLZWFYMWNKH-CMKMFDCUSA-N checkY
  (verify)

Hydrocodone, also known as dihydrocodeinone, is a semisynthetic opioid used to treat pain and as a cough suppressant.[10] It is taken by mouth.[10] Typically it is dispensed as the combination acetaminophen/hydrocodone or ibuprofen/hydrocodone for pain severe enough to require an opioid[11][12][13] and in combination with homatropine methylbromide to relieve cough.[10] It is also available by itself in a long-acting form under the brand name Zohydro ER, among others, to treat severe pain of a prolonged duration.[10][14] Hydrocodone is a controlled drug: in the United States a Schedule II Controlled Substance.

  1. ^ Bonewit-West K, Hunt SA, Applegate E (2012). Today's Medical Assistant: Clinical and Administrative Procedures. Elsevier Health Sciences. p. 571. ISBN 9781455701506. Archived from the original on 10 January 2023. Retrieved 20 August 2019.
  2. ^ a b c d Cite error: The named reference ElliottSmith2016 was invoked but never defined (see the help page).
  3. ^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  4. ^ a b Polsten GR, Wallace MS (21 June 2016). "Analgesic Agents in Rheumatic Disease". In Firestein GS, Budd R, Gabriel SE, McInnes IB, O'Dell JR (eds.). Kelley and Firestein's Textbook of Rheumatology. Elsevier Health Sciences. pp. 1081–. ISBN 978-0-323-41494-4. Archived from the original on 12 January 2023. Retrieved 23 September 2016.
  5. ^ Chabner BA, Longo DL (8 November 2010). "Chapter 37: Drug Therapy of Pain in Cancer Patients". Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & Wilkins. pp. 700–. ISBN 978-1-60547-431-1. Archived from the original on 12 January 2023. Retrieved 23 September 2016.
  6. ^ a b c d Cite error: The named reference Zhou2016 was invoked but never defined (see the help page).
  7. ^ Cite error: The named reference DavisGlare2005 was invoked but never defined (see the help page).
  8. ^ Bluth MH (16 November 2016). Toxicology and Drug Testing, An Issue of Clinics in Laboratory Medicine, E-Book. Elsevier Health Sciences. pp. 85–. ISBN 978-0-323-47795-6. Archived from the original on 12 January 2023. Retrieved 22 June 2018.
  9. ^ Smith HS (21 February 2013). Opioid Therapy in the 21st Century. OUP USA. pp. 68–. ISBN 978-0-19-984497-5. Archived from the original on 12 January 2023. Retrieved 22 June 2018.
  10. ^ a b c d "Hydrocodone Bitartrate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 November 2010. Retrieved 15 April 2019.
  11. ^ Mallinckrodt (10 March 2021). "HYDROCODONE BITARTRATE AND ACETAMINOPHEN tablet (label)". National Institutes of Health DailyMed. Archived from the original on 6 November 2021. Retrieved 6 November 2021.
  12. ^ Briggs GG, Freeman RK, Yaffe SJ (2011). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 692. ISBN 9781608317080.
  13. ^ "Hydrocodone Combination Products: MedlinePlus Drug Information". medlineplus.gov. Archived from the original on 5 July 2016. Retrieved 4 November 2023.
  14. ^ "Hydrocodone: MedlinePlus Drug Information". medlineplus.gov. Archived from the original on 15 April 2019. Retrieved 15 April 2019.
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