Interactome

In molecular biology, an interactome is the whole set of molecular interactions in a particular cell. The term specifically refers to physical interactions among molecules (such as those among proteins, also known as protein–protein interactions, PPIs; or between small molecules and proteins^[1]) but can also describe sets of indirect interactions among genes (genetic interactions).

The word "interactome" was originally coined in 1999 by a group of French scientists headed by Bernard Jacq.^[3] Mathematically, interactomes are generally displayed as graphs. though interactomes may be described as biological networks, they should not be confused with other networks such as neural networks or food webs.

^ Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG. Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux. Sci Rep. 2018 Jul 23;8(1):11061. doi: 10.1038/s41598-018-29281-1.
^ Hennah W, Porteous D (2009). Reif A (ed.). "The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes". PLOS ONE. 4 (3): e4906. Bibcode:2009PLoSO...4.4906H. doi:10.1371/journal.pone.0004906. PMC 2654149. PMID 19300510.
^ Sanchez C; Lachaize C; Janody F; et al. (January 1999). "Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database". Nucleic Acids Res. 27 (1): 89–94. doi:10.1093/nar/27.1.89. PMC 148104. PMID 9847149.

[1] Wang L, Eftekhari P, Schachner D, Ignatova ID, Palme V, Schilcher N, Ladurner A, Heiss EH, Stangl H, Dirsch VM, Atanasov AG. Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux. Sci Rep. 2018 Jul 23;8(1):11061. doi: 10.1038/s41598-018-29281-1.

[pmid19300510-2] Hennah W, Porteous D (2009). Reif A (ed.). "The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes". PLOS ONE. 4 (3): e4906. Bibcode:2009PLoSO...4.4906H. doi:10.1371/journal.pone.0004906. PMC 2654149. PMID 19300510.

[pmid9847149-3] Sanchez C; Lachaize C; Janody F; et al. (January 1999). "Grasping at molecular interactions and genetic networks in Drosophila melanogaster using FlyNets, an Internet database". Nucleic Acids Res. 27 (1): 89–94. doi:10.1093/nar/27.1.89. PMC 148104. PMID 9847149.

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Interactome

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