Back الورم الأصفر Arabic لوتئوما Persian Luteoma Italian ല്യൂട്ടിയോമ Malayalam Luteoma Portuguese 黄体瘤 Chinese
| Luteoma | |
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| Specialty | Obstetrics |
A luteoma is a tumor that occurs in the ovaries during pregnancy. It is associated with an increase of sex hormones, primarily progesterone and testosterone.[1][2] The size of the tumor can range from 1 to 25 cm in diameter, but is usually 6 to 10 cm in diameter[3] and can grow throughout the duration of the pregnancy.[4] However, luteomas are benign and resolve themselves after delivery. This type of tumor is rare with only about 200 documented cases; many of these cases were detected accidentally, so the actual rate of occurrence may be higher. The most obvious symptom of a luteoma is masculinization of the mother and the possible masculinization of the fetus.[1][5] This occurs because of the release of testosterone by the luteoma. Testosterone is a sex hormone most abundant in men although small amounts are naturally present in women. Testosterone is responsible for the male characteristics such as deepening of the voice, growth of dark hair, and acne.[6] While not life-threatening, the development of male characteristics associated with luteomas can cause visible changes in the mother and can have drastic effects on the formation of the fetus. Luteomas can cause the fetus to be born with an ambiguous sex, which, depending on how the parents prefer to raise the infant, may result in the parents choosing a sex for the fetus.
Luteomas can be associated with disorders of sex development (formerly known as pseudohermaphroditism).[7]
- ^ a b Huhtaniemi, Ilpo; Rulli, Susana; Ahtiainen, Petteri; Poutanen, Matti (2005). "Multiple sites of tumorigenesis in transgenic mice overproducing hCG". Molecular and Cellular Endocrinology. 234 (1–2). Elsevier Ireland Ltd.: 117–126. doi:10.1016/j.mce.2004.10.013. hdl:11336/35894. PMID 15836960. S2CID 36095955.
- ^ Sorianello, E; Fritz, S; Beyer, S; Hales, D B; Mayerhofer, A; Libertun, C; Lux-Lantos, V (2002). "Development of an experimental ovarian tumor: immunocytochemical analysis". European Journal of Endocrinology. 147 (3). Bioscientifica: 387–395. doi:10.1530/eje.0.1470387. hdl:11336/31330. PMID 12213677.
- ^ McClamrock, Howard. Contemporary Endocrinology: Androgen Excess Disorders in Women: Polycystic Ovary Syndrome and Other Disorders, Second Edition. Humana Press Inc.
- ^ Greene, R; Holzwarth, David; Roddick, J (1964). "Luteomas of Pregnancy". American Journal of Obstetrics and Gynecology. 88 (8): 1001–1011. doi:10.1016/s0002-9378(16)35084-0. PMID 14139281.
- ^ Phelan, Niamh; Conway, Gerard (2011). "Management of ovarian disease in pregnancy". Best Practice & Research: Clinical Endocrinology and Metabolism. 25 (6). Elsevier Ltd.: 985–992. doi:10.1016/j.beem.2011.07.007. PMID 22115171.
- ^ Zitzmann, M; Nieschlag, E (2001). "Testosterone levels in healthy men and the relation to behavioural and physical characteristics: facts and constructs". European Journal of Endocrinology. 144 (3). Bioscientifica: 183–197. doi:10.1530/eje.0.1440183. PMID 11248735.
- ^ Mazza V, Di Monte I, Ceccarelli PL, et al. (March 2002). "Prenatal diagnosis of female pseudohermaphroditism associated with bilateral luteoma of pregnancy: case report". Hum. Reprod. 17 (3): 821–4. doi:10.1093/humrep/17.3.821. hdl:11380/741239. PMID 11870143.