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Pierre Louis Maupertuis (1698–1759) was a French mathematician and philosopher.
Maupertuis may also refer to:
- Maupertuis Bay, a bay on Kangaroo Island in South Australia
- Maupertuis (crater), a lunar crater (named after Pierre Louis Maupertuis)
- Maupertuis' principle, a formulation of the principle of least action
- Maupertuis, Manche, a commune in Manche, France
- Maupertus-sur-Mer, a commune in Manche, France
- Nouaillé-Maupertuis, near the site of the 1356 Battle of Poitiers and occasionally lending its name to that battle
- Maleperduis, Malperduys or Maupertuis, the fictional lair of Reynard the Fox