Molecular switch

A molecular switch is a molecule that can be reversibly shifted between two or more stable states.[1][page needed] The molecules may be shifted between the states in response to environmental stimuli, such as changes in pH, light, temperature, an electric current, microenvironment, or in the presence of ions[2] and other ligands. In some cases, a combination of stimuli is required. The oldest forms of synthetic molecular switches are pH indicators, which display distinct colors as a function of pH. Currently synthetic molecular switches are of interest in the field of nanotechnology for application in molecular computers or responsive drug delivery systems.[3] Molecular switches are also important in biology because many biological functions are based on it, for instance allosteric regulation and vision. They are also one of the simplest examples of molecular machines.

  1. ^ Sauvage, J. P.; Amendola, Valeria (2001-07-03). Molecular Machines and Motors. Berlin, Germany: Springer Science & Business Media. ISBN 9783540413820. OCLC 428018682.
  2. ^ Knipe, Peter C.; Thompson, Sam; Hamilton, Andrew D. (2015). "Ion-mediated conformational switches". Chemical Science. 6 (3): 1630–1639. doi:10.1039/C4SC03525A. ISSN 2041-6520. PMC 5482205. PMID 28694943.
  3. ^ Viricel W, Mbarek A, Leblond J (2015). "Switchable Lipids: Conformational Change for Fast pH-Triggered Cytoplasmic Delivery" (PDF). Angewandte Chemie International Edition. 54 (43): 12743–12747. doi:10.1002/anie.201504661. PMID 26189870. S2CID 24175578.

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