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| Percutaneous umbilical cord blood sampling | |
|---|---|
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| Other names | Fetal blood sampling |
| MeSH | D017218 |
Percutaneous umbilical cord blood sampling (PUBS), also called cordocentesis, fetal blood sampling, or umbilical vein sampling is a diagnostic genetic test that examines blood from the fetal umbilical cord to detect fetal abnormalities.[1] Fetal and maternal blood supply are typically connected in utero with one vein and two arteries to the fetus. The umbilical vein is responsible for delivering oxygen rich blood to the fetus from the mother; the umbilical arteries are responsible for removing oxygen poor blood from the fetus. This allows for the fetus’ tissues to properly perfuse. PUBS provides a means of rapid chromosome analysis and is useful when information cannot be obtained through amniocentesis, chorionic villus sampling, or ultrasound (or if the results of these tests were inconclusive); this test carries a significant risk of complication and is typically reserved for pregnancies determined to be at high risk for genetic defect.[2] It has been used with mothers with immune thrombocytopenic purpura.[3]
- ^ "Human Reproduction, Lectures: Clinical Genetics". Retrieved 2010-02-11.
- ^ "Percutaneous Umbilical Cord Blood Sampling". University of Maryland Medical Center. A.D.A.M. Inc. 17 September 2013. Retrieved 17 March 2014.
- ^ Vianelli N, Baravelli S, Milano V, Rizzo N, Catani L, Tura S (December 1998). "Percutaneous umbilical blood sampling in the management of immune thrombocytopenic purpura during pregnancy". Haematologica. 83 (12): 1127–8. PMID 9949634.