Back بروتين غشائي محيطي Arabic Proteïna perifèrica de membrana Catalan Membranständiges Protein German Proteína periférica de membrana Spanish Mintzeko proteina periferiko Basque پروتئین‌های غشای پیرامونی Persian Protéine membranaire périphérique French Proteína periférica de membrana Galician חלבון ממברנה פריפריאלי HE Protein membran perifer ID

Peripheral membrane protein

Peripheral membrane proteins, or extrinsic membrane proteins,[1] are membrane proteins that adhere only temporarily to the biological membrane with which they are associated. These proteins attach to integral membrane proteins, or penetrate the peripheral regions of the lipid bilayer. The regulatory protein subunits of many ion channels and transmembrane receptors, for example, may be defined as peripheral membrane proteins. In contrast to integral membrane proteins, peripheral membrane proteins tend to collect in the water-soluble component, or fraction, of all the proteins extracted during a protein purification procedure. Proteins with GPI anchors are an exception to this rule and can have purification properties similar to those of integral membrane proteins.

The reversible attachment of proteins to biological membranes has shown to regulate cell signaling and many other important cellular events, through a variety of mechanisms.[2] For example, the close association between many enzymes and biological membranes may bring them into close proximity with their lipid substrate(s).[3] Membrane binding may also promote rearrangement, dissociation, or conformational changes within many protein structural domains, resulting in an activation of their biological activity.[4][5] Additionally, the positioning of many proteins are localized to either the inner or outer surfaces or leaflets of their resident membrane.[6] This facilitates the assembly of multi-protein complexes by increasing the probability of any appropriate protein–protein interactions.

Schematic representation of the different types of interaction between monotopic membrane proteins and the cell membrane: 1. interaction by an amphipathic α-helix parallel to the membrane plane (in-plane membrane helix) 2. interaction by a hydrophobic loop 3. interaction by a covalently bound membrane lipid (lipidation) 4. electrostatic or ionic interactions with membrane lipids (e.g. through a calcium ion)
  1. ^ "extrinsic protein | biology | Britannica". www.britannica.com. Retrieved 2022-07-04.
  2. ^ Cafiso DS (2005). "Structure and interactions of C2 domains at membrane surfaces". In Tamm LK (ed.). Protein-Lipid Interactions: From Membrane Domains to Cellular Networks. Chichester: John Wiley & Sons. pp. 403–22. ISBN 3-527-31151-3.
  3. ^ Ghosh M, Tucker DE, Burchett SA, Leslie CC (November 2006). "Properties of the Group IV phospholipase A2 family". Progress in Lipid Research. 45 (6): 487–510. doi:10.1016/j.plipres.2006.05.003. PMID 16814865.
  4. ^ Cite error: The named reference Johnson_2002 was invoked but never defined (see the help page).
  5. ^ Thuduppathy GR, Craig JW, Kholodenko V, Schon A, Hill RB (June 2006). "Evidence that membrane insertion of the cytosolic domain of Bcl-xL is governed by an electrostatic mechanism". Journal of Molecular Biology. 359 (4): 1045–1058. doi:10.1016/j.jmb.2006.03.052. PMC 1785297. PMID 16650855.
  6. ^ Takida S, Wedegaertner PB (June 2004). "Exocytic pathway-independent plasma membrane targeting of heterotrimeric G proteins". FEBS Letters. 567 (2–3): 209–213. doi:10.1016/j.febslet.2004.04.062. PMID 15178324. S2CID 36940600.
From Wikipedia, the free encyclopedia · View on Wikipedia

Developed by Nelliwinne