Polymyxin

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Polymyxins are antibiotics. Polymyxins B and E (also known as colistin) are used in the treatment of Gram-negative bacterial infections. They work mostly by breaking up the bacterial cell membrane. They are part of a broader class of molecules called nonribosomal peptides.

They are produced in nature by Gram-positive bacteria such as Paenibacillus polymyxa.