Back ستريبتوليسين Arabic Estreptolisina Spanish استرپتولیزین Persian Streptolisina Italian ストレプトリジン Japanese 스트렙토라이신 Korean Streptolizyna Polish Estreptolisina Portuguese Стрептолизин Russian 鏈球菌溶血素 Chinese
| Streptolysin O | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | slo | ||||||
| UniProt | P0C0I3 | ||||||
| |||||||
| Streptolysin S | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | sagA | ||||||
| UniProt | Q1J7I0 | ||||||
| |||||||
Streptolysins are two homogenous exotoxins from Streptococcus pyogenes.[1][2] Types include streptolysin O (SLO; slo), which is oxygen-labile, and streptolysin S (SLS; sagA), which is oxygen-stable.[3]
SLO is part of the thiol-activated cytolysin family.[4] It is hemolytically active only in a reversibly reduced state. It is antigenic, so its antibody antistreptolysin O can be detected in an antistreptolysin O titre.
SLS is stable in the presence of oxygen. It is not antigenic due to its small size. It is sometimes considered a bacteriocin due to similarities in the synthesis pathway.[5]
- ^ "streptolysin" at Dorland's Medical Dictionary
- ^ Streptolysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ Sierig G, Cywes C, Wessels MR, Ashbaugh CD (January 2003). "Cytotoxic effects of streptolysin o and streptolysin s enhance the virulence of poorly encapsulated group a streptococci". Infection and Immunity. 71 (1): 446–55. doi:10.1128/IAI.71.1.446-455.2003. PMC 143243. PMID 12496195.
- ^ Billington SJ, Jost BH, Songer JG (January 2000). "Thiol-activated cytolysins: structure, function and role in pathogenesis". FEMS Microbiology Letters. 182 (2): 197–205. doi:10.1111/j.1574-6968.2000.tb08895.x. PMID 10620666.
- ^ Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, et al. (April 2008). "Discovery of a widely distributed toxin biosynthetic gene cluster". Proceedings of the National Academy of Sciences of the United States of America. 105 (15): 5879–84. doi:10.1073/pnas.0801338105. PMC 2311365. PMID 18375757.