Back لولب الحمض النووي المزدوج Arabic Dvostruki heliks nukleinske kiseline BS مارپیچ دورشته‌ای اسید نوکلئیک Persian סליל כפול של חומצות גרעין HE Pilinan ganda ID 핵산 이중 나선 Korean Heliks ganda dua asid nukleik Malay Двойная спираль нуклеиновых кислот Russian Dvostruki heliks nukleinskih kiselina Serbo-Croatian Dvojna vijačnica DNK Slovenian

Nucleic acid double helix

"Double helix" redirects here. For other uses, see Double helix (disambiguation).
Two complementary regions of nucleic acid molecules will bind and form a double helical structure held together by base pairs.

In molecular biology, the term double helix[1] refers to the structure formed by double-stranded molecules of nucleic acids such as DNA. The double helical structure of a nucleic acid complex arises as a consequence of its secondary structure, and is a fundamental component in determining its tertiary structure. The structure was discovered by Rosalind Franklin and her student Raymond Gosling,[2] but the term "double helix" entered popular culture with the publication in 1968 of The Double Helix: A Personal Account of the Discovery of the Structure of DNA by James Watson.

The DNA double helix biopolymer of nucleic acid is held together by nucleotides which base pair together.[3] In B-DNA, the most common double helical structure found in nature, the double helix is right-handed with about 10–10.5 base pairs per turn.[4] The double helix structure of DNA contains a major groove and minor groove. In B-DNA the major groove is wider than the minor groove.[3] Given the difference in widths of the major groove and minor groove, many proteins which bind to B-DNA do so through the wider major groove.[5]

  1. ^ Kabai, Sándor (2007). "Double Helix". The Wolfram Demonstrations Project.
  2. ^ Cobb, Matthew; Comfort, Nathaniel (2023). "What Rosalind Franklin truly contributed to the discovery of DNA's structure". Nature. 616 (7958): 657–660. Bibcode:2023Natur.616..657C. doi:10.1038/d41586-023-01313-5. PMID 37100935.
  3. ^ a b Alberts; et al. (1994). The Molecular Biology of the Cell. New York: Garland Science. ISBN 978-0-8153-4105-5.
  4. ^ Wang JC (1979). "Helical repeat of DNA in solution". PNAS. 76 (1): 200–203. Bibcode:1979PNAS...76..200W. doi:10.1073/pnas.76.1.200. PMC 382905. PMID 284332.
  5. ^ Pabo C, Sauer R (1984). "Protein-DNA recognition". Annu Rev Biochem. 53: 293–321. doi:10.1146/annurev.bi.53.070184.001453. PMID 6236744.
From Wikipedia, the free encyclopedia · View on Wikipedia

Developed by Nelliwinne