Protein-coding gene in the species Homo sapiens
Neuropathy target esterase , also known as patatin-like phospholipase domain-containing protein 6 (PNPLA6), is an esterase enzyme that in humans is encoded by the PNPLA6 gene .[5] [6] [7] [8]
Neuropathy target esterase is a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine . It is thought to function in neurite outgrowth and process elongation during neuronal differentiation . The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells.[8]
^ a b c GRCh38: Ensembl release 89: ENSG00000032444 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004565 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lush MJ, Li Y, Read DJ, Willis AC, Glynn P (Aug 1998). "Neuropathy target esterase and a homologous Drosophila neurodegeneration-associated mutant protein contain a novel domain conserved from bacteria to man" . Biochem J . 332. ( Pt 1) (Pt 1): 1–4. doi :10.1042/bj3320001 . PMC 1219444 PMID 9576844 . ^ Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Aug 2006). "Characterization of the human patatin-like phospholipase family" . J Lipid Res . 47 (9): 1940–9. doi :10.1194/jlr.M600185-JLR200 PMID 16799181 . ^ Kienesberger PC, Oberer M, Lass A, Zechner R (Apr 2009). "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions" . J Lipid Res . 50 Suppl (Supplement): S63–8. doi :10.1194/jlr.R800082-JLR200 PMC 2674697 PMID 19029121 . ^ a b "Entrez Gene: PNPLA6 patatin-like phospholipase domain containing 6" . 
