Alclometasone

Alclometasone
Clinical data
Trade names	Aclovate
AHFS/Drugs.com	Monograph
MedlinePlus	a604021
Routes of; administration	Topical
ATC code	D07AB10 (WHO) S01BA10 (WHO);
Legal status
Legal status	US: ℞-only;
Pharmacokinetic data
Bioavailability	3% systemically (topical)
Metabolism	Hepatic
Onset of action	Eczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days
Identifiers
	IUPAC name (7R,8S,9S,10R,11S,13S,14S,16R,17R)-7-Chloro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one;
CAS Number	67452-97-5 ;
PubChem CID	5311000;
DrugBank	DB00240 ;
ChemSpider	4470541 ;
UNII	136H45TB7B;
ChEBI	CHEBI:53776 ;
ChEMBL	ChEMBL1201361 ;
Chemical and physical data
Formula	C22H29ClO5
Molar mass	408.92 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1C[C@H]2[C@@H]3[C@@H](CC4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)Cl;
	InChI InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16+,18-,19+,20+,21+,22+/m1/s1 ; Key:FJXOGVLKCZQRDN-PHCHRAKRSA-N ;
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Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.^[2]^[3]

The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.

^ "Alclometasone - Professional Patient Advice". Drugs.com. Retrieved 29 December 2017.
^ "Alclometasone - FDA Prescribing Information". Drugs.com. Retrieved 29 December 2017.
^ No authors listed (April 1987). "Alclometasone--another topical corticosteroid". The Medical Letter on Drugs and Therapeutics. 29 (738): 42–43. PMID 3574236.

[PPA-1] "Alclometasone - Professional Patient Advice". Drugs.com. Retrieved 29 December 2017.

[FDA-PI-2] "Alclometasone - FDA Prescribing Information". Drugs.com. Retrieved 29 December 2017.

[pmid3574236-3] No authors listed (April 1987). "Alclometasone--another topical corticosteroid". The Medical Letter on Drugs and Therapeutics. 29 (738): 42–43. PMID 3574236.

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Alclometasone

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