In organic chemistry, alkynylation is an addition reaction in which a terminal alkyne (−C≡CH) is added to a carbonyl group (C=O) to form an propargylic alcohol (R2C(−OH)−C≡C−R).[1][2]
When the acetylide is formed from acetylene (HC≡CH), the reaction gives an α-ethynyl alcohol. This process is often referred to as ethynylation. Such processes often involve metal acetylide intermediates.
- ^ Viehe, Heinz Günter (1969). Chemistry of Acetylenes (1st ed.). New York: Marcel Dekker, inc. pp. 169& 207–241. doi:10.1002/ange.19720840843.
- ^ Trost, B.M.; Li, C.-J. (2014). Modern Alkyne Chemistry: Catalytic and Atom-Economic Transformations. Weinheim: Wiley VCH.