Autism

Autism
Other names
SpecialtyPsychiatry, clinical psychology, pediatrics, occupational medicine
SymptomsDifficulties in social interaction, verbal and nonverbal communication; inflexible routines; narrow, restricted interests; repetitive body movements; unusual sensory responses
ComplicationsSocial isolation, educational and employment problems,[1] anxiety,[1] stress,[1] bullying, depression,[1][2] self-harm, suicidality[3][4]
Usual onsetEarly childhood
DurationLifelong
CausesMultifactorial, with many uncertain factors
Risk factorsFamily history, certain genetic conditions, having older parents, certain prescribed drugs, perinatal and neonatal health issues
Diagnostic methodBased on combination of clinical observation of behavior and development and comprehensive diagnostic testing completed by a team of qualified professionals (including psychiatrists, clinical psychologists, neuropsychologists, pediatricians, and speech-language pathologists). For adults, the use of a patient's written and oral history of autistic traits becomes more important
Differential diagnosisIntellectual disability, anxiety, bipolar disorder, depression, Rett syndrome, attention deficit hyperactivity disorder, schizoid personality disorder, selective mutism, schizophrenia, fragile X syndrome, obsessive–compulsive disorder, social anxiety disorder, Einstein syndrome, post-traumatic stress disorder,[5] learning disorders (mainly speech disorders)
ManagementPositive behavior support,[6][7] applied behavior analysis, cognitive behavioral therapy, occupational therapy, psychotropic medication,[8] speech–language pathology
Frequency
  • One in 100 people (1%) worldwide[9][10]

Autism spectrum disorder[a] (ASD), or simply autism, is a neurodevelopmental disorder characterized by repetitive, restricted, and inflexible patterns of behavior, interests, and activities; deficits in social communication and social interaction; and the presence of high or low sensory sensitivity. A formal diagnosis requires that symptoms cause significant impairment in multiple functional domains, in addition to being atypical or excessive for the person's age and sociocultural context.[11][12]

Autism manifests in various ways, with its severity and support needs varying widely across the underlying spectrum.[11][12][13] For example, some autistic people are nonverbal, while others have proficient spoken language. Furthermore, the spectrum is multi-dimensional and not all dimensions have been identified as of 2024.[14][15]

Public health authorities and guideline developers classify autism as a neurodevelopmental disorder,[11][16][12][17][18] but the autism rights movement (and some researchers) disagree with the classification. From this point of view, autistic people are representatives of human neurodiversity where their social problems are caused by social stigma, and that they should be accepted rather than cured.[19][20][21] On the contrary, other scientists argue that autism impairs functioning in many ways inherent to the disorder itself and unrelated to society.[22][23] The neurodiversity perspective has led to significant controversy among those who are autistic and advocates, practitioners, and charities.[24][25]

The precise causes of autism are unknown in most individual cases. Research shows that the disorder is highly heritable and polygenic, and neurobiological risks from the environment are also relevant.[26][27][28] Autism frequently co-occurs with attention deficit hyperactivity disorder (ADHD), epilepsy, and intellectual disability, and research indicates that autistic people have significantly higher rates of LGBTQ+ identities and feelings than the general population.[29][30][31] Disagreements persist about what should be part of the diagnosis, whether there are meaningful subtypes or stages of autism,[32] and the significance of autism-associated traits in the wider population.[33][34]

The combination of broader criteria, increased awareness, and the potential increase of actual prevalence has led to considerably increased estimates of autism prevalence since the 1990s.[35][36] The WHO estimates about 1 in 100 children had autism between 2012 and 2021, as that was the average estimate in studies during that period, with a trend of increasing prevalence over time.[b][9][10] This increasing prevalence has reinforced the myth perpetuated by anti-vaccine activists that autism is caused by vaccines.[37] Boys are also significantly far more frequently diagnosed than girls.[38]

There is no known cure for autism, and some advocates dispute the need to find one.[39][40] Interventions such as applied behavior analysis (ABA), speech therapy, and occupational therapy aim to teach children self-care, social and communicative skills.[41][42] Guidelines from the Centres for Disease Control (CDC), and European Society for Child & Adolescent Psychiatry endorse the use of ABA on the grounds that it reduces symptoms impairing daily functioning and quality of life,[41][43] but the National Institute for Health and Care Excellence cites a lack of high-quality evidence to support its use.[44] Additionally, some in the autism rights movement oppose its application due to a perception that it emphasises normalisation.[45][46][47] No medication has been shown to reduce ASD's core symptoms,[43] but some can alleviate comorbid issues.[48][49][50]


Cite error: There are <ref group=lower-alpha> tags or {{efn}} templates on this page, but the references will not show without a {{reflist|group=lower-alpha}} template or {{notelist}} template (see the help page).

  1. ^ a b c d Bonati M, Cartabia M, Clavenna A (January 2022). "Still too much delay in recognition of autism spectrum disorder". Epidemiology and Psychiatric Sciences. 31 (e1). Cambridge University Press: e1. doi:10.1017/S2045796021000822. ISSN 2045-7960. LCCN 2011243374. OCLC 727338545. PMC 8786613. PMID 35012703. S2CID 245851335.
  2. ^ Pezzimenti F, Han GT, Vasa RA, Gotham K (2019). "Depression in Youth with Autism Spectrum Disorder". Child and Adolescent Psychiatric Clinics of North America. 28 (3): 397–409. doi:10.1016/j.chc.2019.02.009. PMC 6512853. PMID 31076116.
  3. ^ Cassidy S, Bradley L, Shaw R, Baron-Cohen S (2018). "Risk markers for suicidality in autistic adults". Molecular Autism. 9 (1): 42. doi:10.1186/s13229-018-0226-4. ISSN 2040-2392. PMC 6069847. PMID 30083306.
  4. ^ "6 Reasons Autistic People Are at Greater Risk of Suicide | Psychology Today".
  5. ^ "At the intersection of autism and trauma". Spectrum News. 26 September 2018. Archived from the original on 17 November 2022. Retrieved 17 November 2022. And people with more autistic,in other forms of PTSD
  6. ^ "What is Positive Behaviour Support?".
  7. ^ "Positive Behaviour Support (PBS)".
  8. ^ "Autism's drug problem". Spectrum News. 19 April 2017. Archived from the original on 11 November 2022. Retrieved 11 November 2022.
  9. ^ a b Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, Yusuf A, Shih A, Elsabbagh M (15 May 2022). "Global prevalence of autism: A systematic review update". Autism Research. 15 (5): 778–790. doi:10.1002/aur.2696. ISSN 1939-3806. PMC 9310578. PMID 35238171.
  10. ^ a b Cite error: The named reference World Health Organization-2022 was invoked but never defined (see the help page).
  11. ^ a b c (World Health Organization: International Classification of Diseases version 11 (ICD-11)): https://icd.who.int/browse/2024-01/mms/en#437815624
  12. ^ a b c "IACC Subcommittee Diagnostic Criteria - DSM-5 Planning Group". iacc.hhs.gov. Retrieved 1 August 2024.
  13. ^ Waizbard-Bartov E, Fein D, Lord C, Amaral DG (2023). "Autism severity and its relationship to disability". Autism Research. 16 (4): 685–696. doi:10.1002/aur.2898. ISSN 1939-3806. PMC 10500663. PMID 36786314.
  14. ^ https://pubmed.ncbi.nlm.nih.gov/38434761/
  15. ^ https://pmc.ncbi.nlm.nih.gov/articles/PMC7190887/
  16. ^ "Overview | Autism spectrum disorder in under 19s: support and management | Guidance". www.nice.org.uk. 28 August 2013. Retrieved 2 November 2024.
  17. ^ National Consultation Meeting for Developing IAP Guidelines on Neuro Developmental Disorders under the aegis of IAP Childhood Disability Group and the Committee on Child Development and Neurodevelopmental Disorders, Dalwai S, Ahmed S, Udani V, Mundkur N, Kamath SS, C Nair MK (15 May 2017). "Consensus Statement of the Indian Academy of Pediatrics on Evaluation and Management of Autism Spectrum Disorder". Indian Pediatrics. 54 (5): 385–393. doi:10.1007/s13312-017-1112-4. ISSN 0974-7559. PMID 28368272.
  18. ^ Howes OD, Rogdaki M, Findon JL, Wichers RH, Charman T, King BH, Loth E, McAlonan GM, McCracken JT, Parr JR, Povey C, Santosh P, Wallace S, Simonoff E, Murphy DG (1 January 2018). "Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology". Journal of Psychopharmacology. 32 (1): 3–29. doi:10.1177/0269881117741766. ISSN 0269-8811. PMC 5805024. PMID 29237331.
  19. ^ Kapp, Steven K. Autistic community and the neurodiversity movement: Stories from the frontline. Springer Nature, 2020.
  20. ^ Jaarsma, Pier, and Stellan Welin. "Autism as a natural human variation: Reflections on the claims of the neurodiversity movement." Health care analysis 20 (2012): 20-30.
  21. ^ Dwyer, Patrick, et al. "Community views of neurodiversity, models of disability and autism intervention: Mixed methods reveal shared goals and key tensions." Autism (2024): 13623613241273029.
  22. ^ Nelson RH (2021). "A Critique of the Neurodiversity View". Journal of Applied Philosophy. 38 (2): 335–347. doi:10.1111/japp.12470.
  23. ^ Shields K, Beversdorf D (1 July 2021). "A Dilemma For Neurodiversity". Neuroethics. 14 (2): 125–141. doi:10.1007/s12152-020-09431-x. ISSN 1874-5504.
  24. ^ Robison JE (2020). "My Time with Autism Speaks". In Kapp SK (ed.). Autistic Community and the Neurodiversity Movement: Stories from the Frontline. Singapore: Springer. pp. 221–232. doi:10.1007/978-981-13-8437-0_16. ISBN 978-981-13-8437-0. S2CID 210496353.
  25. ^ Opar A (24 April 2019). "In search of truce in the autism wars". Spectrum. Simons Foundation. doi:10.53053/VRKL4748. S2CID 249140855. Archived from the original on 8 July 2022. Retrieved 9 July 2022.
  26. ^ Hodges H, Fealko C, Soares N (February 2020). "Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation". Translational Pediatrics. 9 (Suppl 1): S55–S5S65. doi:10.21037/tp.2019.09.09. ISSN 2224-4344. PMC 7082249. PMID 32206584.
  27. ^ Ratajczak HV (1 March 2011). "Theoretical aspects of autism: Causes—A review". Journal of Immunotoxicology. 8 (1): 68–79. doi:10.3109/1547691X.2010.545086. ISSN 1547-691X. PMID 21299355.
  28. ^ Mandy W, Lai MC (March 2016). "Annual Research Review: The role of the environment in the developmental psychopathology of autism spectrum condition". Journal of Child Psychology and Psychiatry, and Allied Disciplines. 57 (3): 271–292. doi:10.1111/jcpp.12501. eISSN 1469-7610. ISSN 0021-9630. OCLC 01307942. PMID 26782158.
  29. ^ Bertelli MO, Azeem MW, Underwood L, Scattoni ML, Persico AM, Ricciardello A, Sappok T, Bergmann T, Keller R (2022), Bertelli MO, Deb S(, Munir K, Hassiotis A (eds.), "Autism Spectrum Disorder", Textbook of Psychiatry for Intellectual Disability and Autism Spectrum Disorder, Cham: Springer International Publishing, p. 391, doi:10.1007/978-3-319-95720-3_16, ISBN 978-3-319-95720-3, retrieved 8 June 2022, Persons with autism spectrum disorder and/or other neurodevelopmental problems are more likely than the general population to have transgender identity, non-heterosexual sexual orientation, and other gender non-conformities.
  30. ^ Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C, Divan G, et al. (2022). "The Lancet Commission on the future of care and clinical research in autism" (PDF). The Lancet. 399 (10321): 299–300. doi:10.1016/s0140-6736(21)01541-5. hdl:11250/2975811. PMID 34883054. S2CID 244917920 – via Norwegian Institute of Public Health.
  31. ^ Cite error: The named reference Graham Holmes-2022 was invoked but never defined (see the help page).
  32. ^ Rosen NE, Lord C, Volkmar FR (December 2021). "The Diagnosis of Autism: From Kanner to DSM-III to DSM-5 and Beyond". Journal of Autism and Developmental Disorders. 51 (12): 4253–4270. doi:10.1007/s10803-021-04904-1. PMC 8531066. PMID 33624215.
  33. ^ Losh M, Adolphs R, Piven J (2011). "The Broad Autism Phenotype". Autism Spectrum Disorders. Oxford University Press. pp. 457–476. doi:10.1093/med/9780195371826.003.0031. ISBN 978-0-19-996521-2.
  34. ^ Chapman R, Veit W (November 2021). "Correction to: The essence of autism: fact or artefact?". Molecular Psychiatry. 26 (11): 7069. doi:10.1038/s41380-021-01057-6. PMID 34697454. S2CID 239771302.
  35. ^ Wazana A, Bresnahan M, Kline J (June 2007). "The autism epidemic: fact or artifact?". Journal of the American Academy of Child and Adolescent Psychiatry. 46 (6): 721–730. doi:10.1097/chi.0b013e31804a7f3b. PMID 17513984.
  36. ^ Cite error: The named reference Russell 2021 was invoked but never defined (see the help page).
  37. ^ DeStefano F, Shimabukuro TT (September 2019). "The MMR Vaccine and Autism". Annual Review of Virology. 6 (1): 585–600. doi:10.1146/annurev-virology-092818-015515. PMC 6768751. PMID 30986133.
  38. ^ Cite error: The named reference CDC 2020 was invoked but never defined (see the help page).
  39. ^ "Cure of Autistic Disorders: Mission Impossible is Possible in an Illustrated Pioneering Experience". SunKrist Journal of Psychiatry and Mental Health: 1–20. 21 August 2020. doi:10.46940/sjpmh.01.1003 (inactive 3 December 2024). S2CID 242289975.{{cite journal}}: CS1 maint: DOI inactive as of December 2024 (link)
  40. ^ Eric Barnes R, McCabe H (2012). "Should we welcome a cure for autism? A survey of the arguments". Medicine, Health Care and Philosophy. 15 (3): 255–269. doi:10.1007/s11019-011-9339-7. ISSN 1386-7423. PMID 21837546.
  41. ^ a b CDC (18 July 2024). "Treatment and Intervention for Autism Spectrum Disorder". Autism Spectrum Disorder (ASD). Retrieved 28 November 2024.
  42. ^ Cite error: The named reference AutismResearch2023Study was invoked but never defined (see the help page).
  43. ^ a b Joaquin Fuentes, Amaia Hervás, Patricia Howlin, ESCAP ASD Working Party (2020), "ESCAP practice guidance for autism: a summary of evidence‑based recommendations for diagnosis and treatment" (PDF), European Child & Adolescent Psychiatry, 30 (6): 961–984, doi:10.1007/s00787-020-01587-4, PMC 8140956, PMID 32666205{{citation}}: CS1 maint: multiple names: authors list (link)
  44. ^ "How we made the decision | Evidence | Autism spectrum disorder in under 19s: recognition, referral and diagnosis | Guidance". www.nice.org.uk. 28 September 2011. Retrieved 28 November 2024.
  45. ^ "EUCAP Position Statement on ABA". EUCAP. 2 April 2024. Retrieved 8 August 2024.
  46. ^
  47. ^ Kirkham P (1 April 2017). "'The line between intervention and abuse' – autism and applied behaviour analysis". History of the Human Sciences. 30 (2): 107–126. doi:10.1177/0952695117702571. ISSN 0952-6951. S2CID 152017417.
  48. ^ "Medication Treatment for Autism". www.nichd.nih.gov/. 19 April 2021. Archived from the original on 7 February 2023. Retrieved 21 February 2023.
  49. ^ Rzepka-Migut B, Paprocka J (2020). "Efficacy and Safety of Melatonin Treatment in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder—A Review of the Literature". Brain Sciences. 10 (4): 219. doi:10.3390/brainsci10040219. ISSN 2076-3425. PMC 7226342. PMID 32272607.
  50. ^ Peled J, Cassuto H, Berger I (2 April 2020). "Processing speed as a marker to stimulant effect in clinical sample of children with high functioning autism spectrum disorder". Nordic Journal of Psychiatry. 74 (3): 163–167. doi:10.1080/08039488.2019.1686063. ISSN 0803-9488. PMID 31686565.

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