Back أبحاث إعادة استخدام الأدوية لعلاج كوفيد-19 Arabic কোভিড-১৯ ঔষধ পুনর্লক্ষীকরণ গবেষণা Bengali/Bangla دەرمانی کۆڤید-١٩ دوبارە لێکۆلینەوە CKB Existující léky a jejich použití proti covidu-19 Czech Έρευνα επαναπροσδιορισμού φαρμάκων για την COVID-19 Greek Investigación sobre la reutilización de medicamentos contra COVID-19 Spanish COVID-19 ravimite ümbertöötlemise uuringud Estonian Recherche sur le repositionnement des médicaments COVID-19 French Covid19-gyógyszer-újrafelhasználási kutatás Hungarian COVID-19に対する薬剤転用研究 Japanese
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Drug repositioning (also known as drug repurposing, re-profiling, re-tasking, or therapeutic switching) is the repurposing of an approved drug for the treatment of a different disease or medical condition than that for which it was originally developed.[1] This is one line of scientific research which is being pursued to develop safe and effective COVID-19 treatments.[2][3][4] Other research directions include the development of a COVID-19 vaccine[5] and convalescent plasma transfusion.[6]
Several existing antiviral medications, previously developed or used as treatments for severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), HIV/AIDS, and malaria, have been researched as potential COVID-19 treatments, with some moving into clinical trials.[7][8][9]
In a statement to the journal Nature Biotechnology in February 2020, US National Institutes of Health Viral Ecology Unit chief Vincent Munster said, "The general genomic layout and the general replication kinetics and the biology of the MERS, SARS and [SARS-CoV-2] viruses are very similar, so testing drugs which target relatively generic parts of these coronaviruses is a logical step".[2]
- ^ "Repurposing Drugs". National Center for Advancing Translational Sciences (NCATS). U.S. Department of Health & Human Services, National Institutes of Health. 7 November 2017. Archived from the original on 4 October 2020. Retrieved 26 March 2020.
- ^ a b Harrison C (April 2020). "Coronavirus puts drug repurposing on the fast track". Nature Biotechnology. 38 (4): 379–381. doi:10.1038/d41587-020-00003-1. PMID 32205870. S2CID 213394680.
- ^ MacRaild CA, Mohammed MU, Murugesan S, Styles IK, Peterson AL, Kirkpatrick CM, et al. (October 2022). "Systematic Down-Selection of Repurposed Drug Candidates for COVID-19". International Journal of Molecular Sciences. 23 (19): 11851. doi:10.3390/ijms231911851. PMC 9569752. PMID 36233149.
- ^ Sleigh SH, Barton CL (2010). "Repurposing Strategies for Therapeutics". Pharmaceutical Medicine. 24 (3): 151–59. doi:10.1007/BF03256811. S2CID 25267555.
- ^ "COVID-19 Vaccine Frontrunners". Archived from the original on 6 May 2020. Retrieved 16 April 2020.
- ^ Duan K, Liu B, Li C, Zhang H, Yu T, Qu J, et al. (April 2020). "Effectiveness of convalescent plasma therapy in severe COVID-19 patients". Proceedings of the National Academy of Sciences of the United States of America. 117 (17): 9490–9496. Bibcode:2020PNAS..117.9490D. doi:10.1073/pnas.2004168117. PMC 7196837. PMID 32253318.
- ^ Li G, De Clercq E (March 2020). "Therapeutic options for the 2019 novel coronavirus (2019-nCoV)". Nature Reviews. Drug Discovery. 19 (3): 149–150. doi:10.1038/d41573-020-00016-0. PMID 32127666.
- ^ "COVID-19 treatment and vaccines tracker (Choose tab of interest, apply filters to view select data)". Milken Institute. 2 June 2020. Archived from the original on 3 June 2020. Retrieved 3 June 2020.
- ^ Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB (May 2020). "Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review". JAMA. 323 (18): 1824–1836. doi:10.1001/jama.2020.6019. PMID 32282022.