A date rape drug is any drug that incapacitates another person and renders that person vulnerable to sexual assault, including rape. These substances are associated with date rape because of reported incidents of their use in the context of two people dating, during which the victim is sexually assaulted, raped or suffers other harm. However, such substances have also been exploited during retreats, for example ayahuasca retreats. While these substances are not exclusively used to perpetrate sexual assault or rape, as they are also used for personal recreation or medical purposes, their side effects facilitate such acts. The most common incapacitating agent for date rape is alcohol, administered either surreptitiously[1] or consumed voluntarily,[2] rendering the victim unable to make informed decisions or give consent.