Hygromycin B

Hygromycin B
Clinical data
Trade names	Hygromix
Other names	O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine, HYG
AHFS/Drugs.com	International Drug Names
ATC code	none;
Identifiers
	IUPAC name (3' R,3aS,4S,4' R,5' R,6R,6' R,7S,7aS)-4-{[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol;
CAS Number	31282-04-9 ;
PubChem CID	35766;
ChemSpider	32900 ;
UNII	3XQ2233B0B;
ChEMBL	ChEMBL1276484 ;
CompTox Dashboard (EPA)	DTXSID7041045 ;
ECHA InfoCard	100.045.935
Chemical and physical data
Formula	C20H37N3O13
Molar mass	527.524 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	160 to 180 °C (320 to 356 °F) (decomp.)
	SMILES O1[C@H]4[C@@H](OC12O[C@@H]([C@H](O)[C@@H](O)[C@H]2O)[C@@H](N)CO)[C@@H](O)[C@H](O[C@H]4O[C@@H]3[C@@H](O)[C@H](N)C[C@H](NC)[C@H]3O)CO;
	InChI InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1 ; Key:GRRNUXAQVGOGFE-KPBUCVLVSA-N ;
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Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and other eukaryotic cells by inhibiting protein synthesis.^[1]

^ Pittenger RC, Wolfe RN, Hoehn MM, Marks PN, Daily WA, McGUIRE JM (December 1953). "Hygromycin. I. Preliminary studies on the production and biologic activity of a new antibiotic". Antibiotics & Chemotherapy. 3 (12): 1268–1278. PMID 24542808.