Inquiries into the origins of SARS-CoV-2
Since the beginning of the COVID-19 pandemic , there have been efforts by scientists, governments, and others to determine the origin of the SARS-CoV-2 virus. Similar to other outbreaks,[ 1] [ 2] the virus was derived from a bat-borne virus and most likely was transmitted to humans via another animal in nature, or during wildlife bushmeat trade such as that in food markets.[ 5] While other explanations, such as speculations that SARS-CoV-2 was accidentally released from a laboratory have been proposed,[ 6] [ 7] [ 8] such explanations are not supported by evidence.[ 9] [ 10] Conspiracy theories about the virus's origin have also proliferated.[ 11]
Research is ongoing as to whether SARS-CoV-2 came directly from bats or indirectly through an intermediate host, such as pangolins , civets ,[ 12] or raccoon dogs .[ 13] [ 14] Genomic sequence evidence indicates the spillover event introducing SARS-CoV-2 to humans likely occurred in late 2019.[citation needed ] As with the 2002–2004 SARS-CoV-1 outbreak , efforts to trace the specific geographic and taxonomic origins of SARS-CoV-2 could take years, and results may be inconclusive.[citation needed ]
In July 2022, two papers published in Science described novel epidemiological and genetic evidence that suggested the pandemic likely began at the Huanan Seafood Wholesale Market and did not come from a laboratory.[ 15] [ 16] [ 17]
^ Aguirre AA, Catherina R, Frye H, Shelley L (September 2020). "Illicit Wildlife Trade, Wet Markets, and COVID-19: Preventing Future Pandemics" . World Medical & Health Policy . 12 (3): 256– 265. doi :10.1002/wmh3.348 . ISSN 1948-4682 . PMC 7362142 . PMID 32837772 .
^ Khan SA, Imtiaz MA, Islam MM, Tanzin AZ, Islam A, Hassan MM (10 May 2022). "Major bat-borne zoonotic viral epidemics in Asia and Africa: A systematic review and meta-analysis" . Veterinary Medicine and Science . 8 (4): 1787– 1801. doi :10.1002/vms3.835 . ISSN 2053-1095 . PMC 9297750 . PMID 35537080 .
^ "Virus origin / Origins of the SARS-CoV-2 virus" . WHO. Retrieved 23 June 2021 . WHO-convened Global Study of the Origins of SARS-CoV-2
^ Hu B, Guo H, Zhou P, Shi ZL (6 October 2020). "Characteristics of SARS-CoV-2 and COVID-19" . Nature Reviews. Microbiology . 19 (3): 141– 154. doi :10.1038/s41579-020-00459-7 . ISSN 1740-1526 . PMC 7537588 . PMID 33024307 .
^ This assessment has been made by numerous virologists, geneticists, evolutionary biologists, professional societies, and published in multiple peer-reviewed journal articles.[citation needed ]
[ 3] [ 4]
^ Horowitz J, Stanway D (9 February 2021). "COVID may have taken 'convoluted path' to Wuhan, WHO team leader says" . Reuters. Archived from the original on 10 February 2021. Retrieved 10 February 2021 .
^ Pauls K, Yates J (27 January 2020). "Online claims that Chinese scientists stole coronavirus from Winnipeg lab have 'no factual basis' " . Canadian Broadcasting Corporation. Archived from the original on 8 February 2020. Retrieved 8 February 2020 .
^ "China's rulers see the coronavirus as a chance to tighten their grip" . The Economist . 8 February 2020. Archived from the original on 29 February 2020. Retrieved 29 February 2020 .
^ Holmes EC, Goldstein SA, Rasmussen AL, Robertson DL, Crits-Christoph A, Wertheim JO, Anthony SJ, Barclay WS, Boni MF, Doherty PC, Farrar J (August 2021). "The Origins of SARS-CoV-2: A Critical Review" . Cell . 184 (19): 4848– 4856. doi :10.1016/j.cell.2021.08.017 . PMC 8373617 . PMID 34480864 .
^ Alwine J, Goodrum F, Banfield B, Bloom D, Britt WJ, Broadbent AJ, Campos SK, Casadevall A, Chan GC, Cliffe AR, Dermody T, Duprex P, Enquist LW, Frueh K, Geballe AP, Gaglia M, Goldstein S, Greninger AL, Gronvall GK, Jung JU, Kamil JP, Lakdawala S, Liu SL, Luftig M, Moore JP, Moscona A, Neuman BW, Nikolich JŽ, O'Connor C, Pekosz A, Permar S, Pfeiffer J, Purdy J, Rasmussen A, Semler B, Smith GA, Stein DA, Van Doorslaer K, Weller SK, Whelan SP, Yurochko A (22 August 2024). "The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence". Journal of Virology . 98 (9): e01240–24. doi :10.1128/jvi.01240-24 . PMC 11406950. PMID 39087765 .
^ Hartman TK, Marshall M, Stocks TV, McKay R, Bennett K, Butter S, Gibson Miller J, Hyland P, Levita L, Martinez AP, Mason L, McBride O, Murphy J, Shevlin M, Vallières F (2021). "Different Conspiracy Theories Have Different Psychological and Social Determinants: Comparison of Three Theories About the Origins of the COVID-19 Virus in a Representative Sample of the UK Population" . Frontiers in Political Science . 3 . doi :10.3389/fpos.2021.642510 . ISSN 2673-3145 .
^ Liu SL, Saif LJ, Weiss SR, Su L (26 February 2010). "No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2" . Emerging Microbes & Infections . 9 (1): 505– 507. doi :10.1080/22221751.2020.1733440 . PMC 7054935 . PMID 32102621 .
^ Lytras S, Xia W, Hughes J, Jiang X, Robertson DL (17 August 2021). "The animal origin of SARS-CoV-2" . Science . 373 (6558): 968– 970. Bibcode :2021Sci...373..968L . doi :10.1126/science.abh0117 . PMID 34404734 . S2CID 237198809 .
^ Cite error: The named reference WHO-SR22
was invoked but never defined (see the help page ).
^ Maxmen A (27 February 2022). "Wuhan market was epicentre of pandemic's start, studies suggest" . Nature . 603 (7899): 15– 16. Bibcode :2022Natur.603...15M . doi :10.1038/d41586-022-00584-8 . PMID 35228730 . S2CID 247168739 .
^ Pekar JE, Magee A, Parker E, Moshiri N, Izhikevich K, Havens JL, Gangavarapu K, Malpica Serrano LM, Crits-Christoph A, Matteson NL, Zeller M, Levy JI, Wang JC, Hughes S, Lee J, Park H, Park MS, Ching Zi Yan K, Lin RT, Mat Isa MN, Noor YM, Vasylyeva TI, Garry RF, Holmes EC, Rambaut A, Suchard MA, Andersen KG, Worobey M, Wertheim JO (August 2022). "The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2" . Science . 377 (6609): 960– 966. Bibcode :2022Sci...377..960P . doi :10.1126/science.abp8337 . PMC 9348752 . PMID 35881005 .
^ Worobey M, Levy JI, Malpica Serrano L, Crits-Christoph A, Pekar JE, Goldstein SA, Rasmussen AL, Kraemer MU, Newman C, Koopmans MP, Suchard MA, Wertheim JO, Lemey P, Robertson DL, Garry RF, Holmes EC, Rambaut A, Andersen KG (August 2022). "The Huanan Seafood Wholesale Market in Wuhan was the early epicenter of the COVID-19 pandemic" . Science . 377 (6609): 951– 959. Bibcode :2022Sci...377..951W . doi :10.1126/science.abp8715 . PMC 9348750 . PMID 35881010 .