Tetanus toxin

Tetanus toxin
Tetanus Toxin Heavy Chain C Fragment (PDB: 1a8d​)
Identifiers
OrganismClostridium tetani E88
SymboltetX
Entrez24255210
RefSeq (Prot)WP_011100836.1
UniProtP04958
Other data
ChromosomeGenomic: 0.07 - 0.07 Mb
Search for
StructuresSwiss-model
DomainsInterPro
Tentoxilysin
Identifiers
EC no.3.4.24.68
CAS no.107231-12-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
Structure of tetanospasmin
Mechanism of action of tetanospasmin

Tetanus toxin (TeNT) is an extremely potent neurotoxin produced by the vegetative cell of Clostridium tetani[1] in anaerobic conditions, causing tetanus. It has no known function for clostridia in the soil environment where they are normally encountered. It is also called spasmogenic toxin, tentoxilysin, tetanospasmin, or tetanus neurotoxin. The LD50 of this toxin has been measured to be approximately 2.5–3 ng/kg,[2][3] making it second only to the related botulinum toxin (LD50 2 ng/kg)[4] as the deadliest toxin in the world. However, these tests are conducted solely on mice, which may react to the toxin differently from humans and other animals.

C. tetani also produces the exotoxin tetanolysin, a hemolysin, that causes destruction of tissues.[5]

  1. ^ "Tetanospasmin" at Dorland's Medical Dictionary
  2. ^ "Chapter 21: Tetanus". CDC. Retrieved 2017-01-18.
  3. ^ "Toxin Table". Environmental Health & Safety » University of Florida. Archived from the original on 2017-01-18. Retrieved 2017-01-18.
  4. ^ "Botulism". World Health Organization. Retrieved 2017-01-18.
  5. ^ Willey J (2009). Prescott's Principles of Microbiology. New York City, NY: McGraw-Hill. pp. 481. ISBN 978-0-07-337523-6.

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